Prof. Dr. Christiane Richter-Landsberg

Molekulare Neurobiologie/Neurochemie

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Institut für Biologie und Umweltwissenschaften (IBU)

Carl von Ossietzky Universität Oldenburg
Postfach 2503
26111 Oldenburg

Tel.: +49-(0)441-798-3253 Fax: +49-(0)441-798-3250

Department für Neurowissenschaften

Carl von Ossietzky Universität Oldenburg

Raum: W04 1-117 (» Adresse und Lageplan) Sprechzeiten: Es sind keine Termine vorhanden. Bitte kontaktieren Sie den Lehrenden direkt. Tel.: 0441 798 3422

Publikationen

ausgewählte Publikationen

1. O. Goldbaum, C. Richter-Landsberg: Proteolytic stress causes heat shock protein induction, tau-ubiquitination and the recruitment of ubiquitin to tau-positive aggregates in oligodendrocytes in culture. J. Neuroscience 24: 5748-5757 (2004).
2. C. Richter-Landsberg, N.G. Bauer: Tau-inclusion body formation in oligodendroglia: the role of stress proteins and proteasomal inhibition. Intl. J. Dev. Neuroscience 22: 443-451 (2004).
3. C. Richter-Landsberg: Heat shock proteins: Expression and functional roles in nerve cells and glia. In: heat shock proteins in neural cells. pp 1-13 (Ed. C.Richter-Landsberg) BioLandes. Eurekah.com (2005)
4. K. Uryu K, C. Richter-Landsberg , W. Welch , E. Sun , O. Goldbaum , EH Norris , CT Pham , I. Yazawa I, Hilburger K, M. Micsenyi, BI Giasson , NM Bonini, VMY Lee, JQ Trojanowski JQ Convergence of Hsp90 with ubiquitin in filamentous alpha-synuclein inclusions of alpha-synucleinopathies. American Journal of Pathology 168: 947-961 (2006)
5. O. Goldbaum, G. Vollmer, C. Richter-Landsberg: Proteasome inhibition by MG-132 induces apoptotic cell death and mitochondrial dysfunction in cultured rat brain oligodendrocytes but not in astrocytes. Glia 53: 891-901 (2006)
6. N. Bauer, C. Richter-Landsberg: The dynamic instability of microtubules is required for aggresome formation in oligodendroglial cells after proteolytic stress. J. Mol. Neurosci. 29: 153-168 (2006)
7. C. Richter-Landsberg, O. Goldbaum, T. Stahnke: Gehirnzellen im Stress. Einblicke (Universität Oldenburg) Nr.44/ Herbst 2006 pp 4-8. (2006)
8. C. Richter-Landsberg, O. Goldbaum: Small heat shock proteins and the cytoskeleton: their role in inclusion body formation in glial cells. In: Heat shock proteins in neural cells (Ed C. Richter-Landsberg). Landes Bioscience/ Eurekah.com, Springer Science, New York, pp13-24 (2007)
9. Stahnke T, Stadelmann C, Netzler A, Brück W, Richter-Landsberg C.: Differential upregulation of Heme Oxygenase-1 (HSP32) in glial cells after oxidative stress and in demyelinating disorders. J. Mol. Neurosci. 32: 25-37 (2007)
10. C. Richter-Landsberg: The cytoskeleton in oligodendrocytes: Microtubule dynamics in health and disease. J. Mol. Neurosci. 35: 55-63 (2008)
11. C. Richter-Landsberg: Oligodendrocytes take center stage. J. Mol. Neurosci. 35: 1-2 (2008)
12. O. Goldbaum, P.H. Jensen, C. Richter-Landsberg: The expression of tubulin polymerization promoting protein TPPP/p25α is developmentally regulated in cultured rat brain oligodendrocytes and affected by proteolytic stress. Glia 56: 1736-1746 (2008)
13. S. Steiner, HG Bernstein, C. Richter-Landsberg, B. Bogerts, M.T. Wunderlich, G. Keilhoff: S100B is expressed in and released from OLN-93 oligodendrocytes: influence of serum and glucose deprivation. Neuroscience 154: 496-503 (2008)
14. O. Goldbaum, M. Riedel, T. Stahnke, C. Richter-Landsberg: The small heat shock protein HSP25 protects astrocytes against stress induced by proteasomal inhibition. Glia 57: 1566-1577 (2009)
15. C. L. Kragh, L.B. Lund, F. Febbraro, H.D. Hansen, W.P. Gai, C. Richter-Landsberg, P.H. Jensen: α-Synuclein aggregation and Ser129 phosphorylation dependent cell death in oligodendroglial cells. J. Biol. Chem. 284: 10211-10222 (2009)
16. N.G. Bauer, C. Richter-Landsberg, C. ffrench-Constant: The role of the oligodendroglial cytoskeleton in differentiation and myelination. Glia 57: 1691-1705 (2009)
17. M. Riedel, O. Goldbaum, C. Richter-Landsberg: α-Synuclein promotes the recruitment of tau to protein inclusions in oligodendroglial cells: effects of oxidative and proteolytic stress. J. Mol. Neurosci. 39: 226-234 (2009)
18. C. Richter-Landsberg: Stress im Gehirn und seine Folgen- die Tauopathie PSP. PSP-PSP-Rundschau 14, Heft 1, 4-10 (2009)
19. S. Bolhuis, C. Richter-Landsberg: Effect of proteasome inhibition by MG-132 on HSP27 oligomerization, phosphorylation and aggresome formation in the OLN-93 oligodendrocyte cell line. J. Neurochem. 10.1111/j.1471-4159.2010.06600.x (2010)
20. L. Schwarz, G. Vollmer, C. Richter-Landsberg: The small heat shock protein HSP25/27 (HspB1) is abundant in cultured astrocytes and associated with astrocytic pathology in progressive supranuclear palsy and corticobasal degeneration. International Journal of Cell Biology Vol. 2010: Article ID 717520, 10 pages. doi: 10.1155/2010/717420 (2010)
21. A. Brand, N.G. Bauer, A. Hallot, O. Goldbaum, K. Ghebremeskel, R. Reifen, C. Richter-Landsberg: Membrane lipid modification by polyunsaturated fatty acids sensitizes oligodendroglial OLN-93 cells against oxidative stress and promotes upregulation of heme oxygenase-1 (HSP32) J. Neurochem. 113: 465-476 (2010)
22. M. Riedel, O. Goldbaum, S. Schmitt, C. Richter-Landsberg: 17-AAG induces cytoplasmic α-synuclein aggregate clearance by induction of autophagy. PlosOne 5 (1): e8753. doi: 13.1371/journal.pone.0008753; page 1-9 (2010)
23. A. Hoffmann, C. Grimm, R. Kraft, O. Goldbaum, A. Wrede, C. Nolte, UK Hanisch, C. Richter-Landsberg, W. Brück, H. Kettenmann, C. Harteneck: TRPM3 is expressed in sphingosine-responsive myelinating oligodendrocytes. J. Neurochem. Feb 15, (Ebub ahead of print) PMID: 20163522 (2010)
104. J. Steiner, ML Schroeter, K. Schlitz, HG Bernstein, UJ Müller, C. Richter-Landsberg, WE Müller, M. Walter, T. Gos, B. Bogerts, G. Keilhoff: Haloperidol and clozapine decrease S100B release from glial cells. Neuroscience 167: 1025-1031 (2010)
105. S. Jänen, H. Chaachouay, C. Richter-Landsberg: Autophagy is activated by proteasomal inhibition and involved in aggresome clearance in cultured astrocytes. Glia 58: 1766-1744 (2010)
106. M. Riedel, M. Wille, C. Richter-Landsberg: Membrane lipid modification by dodecaheaxaenoic acid (DHA) promotes the formation of α-synuclein inclusion bodies immunopositive for SUMO-1 in oligodendroglial cells after oxidative stress. J. Mol. Neurosci. 43: 290-302 (2011)
107. L. Schwarz, O. Goldbaum, M. Bergmann, S. Probst-Cousin, C. Richter-Landsberg: Involvement of macroautophagy in multiple system atrophy and protein aggregate formation in oligodendrocytes. J. Mol. Neuroscience 47: 256-266 (2012)
108. Fernández-Gamba A, Leal MC, Maarouf CL, Richter-Landsberg C, Wu T, MorelliL, Roher AE, Castaño EM. Collapsin response mediator protein-2 phosphorylation promotes the reversible retraction of oligodendrocyte processes in response to non-lethal oxidative stress. J Neurochem. 121: 985-995 (2012)

109. V. Seiberlich, O. Goldbaum, V. Zhukareva, C. Richter-Landsberg: The small inhibitor PR-619 of deubiquitinating enzymes affects the microtubule network and causes protein aggregate formation in neural cells: implications for neurodegenerative diseases. BBA Molecular Cell Research 1823: 2057-2068 (2012)
110. H. Kisos, K. Pukaß, T. Ben-Hur, C. Richter-Landsberg, R. Sharon: Increased neuronal α-synuclein pathology associates with its accumulation in oligodendrocytes in mice modelling α-synucleinopathies. PlosOne October 2012, vol7, issue 10, e46817; page 1-13 (2012)
111. K. Tulpule, MM Schmidt, K. Boecker, O. Goldbaum, C. Richter-Landsberg, R. Dringen: Formaldehyde induces rapid glutathione export from viable oligodendroglial OLN-93 cells. Neurochem Int. 61: 1303-1313 (2012)
112. C. Richter-Landsberg: Zelluläre Selbstverdauung: Autophagie als Überlebensstrategie. Biologie in Unserer Zeit: 42 (6): 374-379 (2012)
113. C. Richter-Landsberg: Überlebensstrategie: Selbstverdauung. Einblicke (Universität Oldenburg) pp 6-11 Herbst 2012
114. Mathew B. Wong, Jacob Goodwin, Christiane Richter-Landsberg, Wei Ping Gai, Dean L Pountney: SUMO-1 colocalizes with a subset of lysosomes associated with glial protein inclusion bodies. Neurotoxicol. Res. 23: 1-21 (2013)
115. C. Richter-Landsberg: Microtubules and associated proteins in oligodendrocytes, the myelin forming cells of the central nervous system. Neuromethods. 79 (Springer Protocols) The Cytoskeleton. ISBN 978-1-62703-265-0. Ed R. Dermitzel. Humana Press, pp 323-333 (2013)
116. C.L. Kragh, G. Fillon, A. Gysbers, H.DS. Hansen, M. Neumann, C. Richter-Landsberg, C. Haass, B. Zalc, C. Lubetzki, WP Gai, GM Halliday, PJ Kahle, PH Jensen: FAS-dependent cell death in α-synuclein transgenic oligodendrocyte models of multiple system atrophy. PlosOne 8 (1): e55243. Doi: 10.1371/journal.ponr.0055243 (2013)
117. V. Seiberlich, J. Borchert, V. Zukhareva, C. Richter-Landsberg: Inhibition of protein deubiquitination by PR-619 activates the autophagic pathway in OLN-t40 oligodendroglial cells. Cell Biochemistry and Biophysics 67: 149-160 (2013)
118. C. Richter-Landsberg, J. Leyk: Inclusion body formation, macroautophagy, and the role of HDA6 in neurodegeneration. Acta Neuropathologica 126: 793-807 (2013)
119. K. Pukaß, C. Richter-Landsberg: Oxidative stress promotes uptake, accumulation, and oligomerization of extracellular alpha-synuclein in oligodendrocytes. J. Mol. Neurosci. 52: 339-352 (2014)
120. M. Noack, J. Leyk, C. Richter-Landsberg: HDAC6 inhibition results in tau acetylation and modulates tau phosphorylation and degradation in oligodendrocytes. Glia 62: 535-547 (2014)
121. C. Richter-Landsberg: The alpha-tubulin deacetylase HDAC6 in aggresome formation and autophagy: Implications for neurodegeneration. In Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, 1st Edition, Ed M. Hayat. Elsevier, Academic Press. Vol. V, Chapter 18 (2014)
122. M. Noack, C. Richter-Landsberg: Activation of autophagy does not protect oligodendrocytes against protein aggregate formation and cell death induced by proteasomal inhibition. J. Mol. Neurosci. 55:99-108 (2015)
123. J. Leyk, O. Goldbaum, M. Noack, C. Richter-Landsberg: Inhibition of HDAC6 modifies tau inclusion body formation and impairs autophagic clearance. J. Mol. Neurosci. 55: 1031-1046 (2015)
124. K. Pukaß, C. Richter-Landsberg: Inhibition of UCH-L1 in oligodendroglial cells results in microtubule stabilization and prevents α-synuclein aggregate formation by activating the autophagic pathway: implications for multiple system atrophy. Front. Cellular Neurosci. May 5;9:163. doi: 10.3389/fncel.2015.00163. eCollection (2015)
125. V. Seiberlich, N.G. Bauer, L. Schwarz, C. ffrench-Constant, O. Goldbaum, C. Richter-Landsberg: Downregulation of the microtubule associated protein Tau impairs process outgrowth and myelin basic protein mRNA transport in oligodendrocytes. Glia 63: 1031-1635. doi: 10.1002/glia.22832. Epub 2015 Apr 4. (2015)
126. K. Pukaß, O. Goldbaum, C. Richter-Landsberg: Mitochondrial impairment and oxidative stress compromise autophagosomal degradation of α-synuclein in oligodendroglial cells. J. Neurochem. 135:194-205. doi: 10.1111/jnc.13256. Epub 2015 Aug 12. (2015)
127. C. Richter-Landsberg: Protein Aggregate Formation In Oligodendrocytes: Tau And The Cytoskeleton At The Intersection Of Neuroprotection And Neurodegeneration. Biological Chemistry 396: 185-194 oi: 10.1111/jnc.13256. Epub 2015 Aug 12. (2016)
128. I. Gozes, Baas P.W. Richter-Landsberg C.: International Meeting Molecular Neurodegeneration: News and Views in Molecular Neuroscience in Health and Disease. Delmenhorst, Germany, July 20-22, 2015. J. Mol Neurosci. 57:153-9. doi: 10.1007/s12031-015-0637-z (2015)
129. A. Malishkevich, J. Leyk, O. Goldbaum, C. Richter-Landsberg C, I. Gozes : ADNP/ADNP2 expression in oligodendrocytes: implication for myelin-related neurodevelopment. J. Mol Neurosci. 57:304-13. doi: 10.1007/s12031-015-0640-4. (2015)
130. H. Wichmann, F. Vocke, T. Brinkhoff, M. Simon, C. Richter-Landsberg: Cytotoxic Effects of Tropodithietic Acid on Mammalian Clonal Cell Lines of Neuronal and Glial Origin. Marine Drugs 2015 Nov 27;13(12):7113-23. doi: 10.3390/md13127058. (2015)
131. H. Wichmann, T. Brinkhoff, M. Simon, C. Richter-Landsberg: Dimethylsulfoniopropionate Promotes Process Outgrowth in Neural Cells and Exerts Protective Effects against Tropodithietic Acid. Marine Drugs 2016 May 6;14(5). pii: E89. doi: 10.3390/md14050089. (2016)
132. S.Dongmo, J. Leyk, C. Dosche, C. Richter-Landsberg, U. Wollenberger and G. Wittstock : Electrogeneration of O2.− and H2O2 Using Polymer-modified Microelectrodes in the Environment of Living Cells. Electroanalysis. doi: 10.1002/elan.201600267 (2016)





Bücher und Sonderhefte
Heat shock proteins in neural cells. Ed. C.Richter-Landsberg.
Neuroscience Intelligence Unit, Springer New York, Landes Bioscience/Eurekah.COM Austin, Texas, USA (2007)

Oligodendrocytes. Special Issue.
Guest Ed. C. Richter-Landsberg.
Journal of Molecular Neuroscience 35 (1) (2008)