Biochemie der Signaltransduktion/ Neurosensorische Prozesse

Publikationen 2013

Aquila M., Benedusi M., Koch K-W., Dell’Orco D. and Rispoli G. (2013) Divalent cations modulate membrane binding and pore formation of a potent antibiotic peptide analog of alamethicin. Cell Calcium 53(3):180-186

Koch KW and Dell'Orco D (2013) A calcium relay mechanism in vertebrate phototransduction.  ACS Chem Neurosci. 4, 909-917

Koch KW (2013) The guanylate cyclase signaling system in zebrafish photoreceptors. FEBS Lett  Jun 27, 587(13):2055-2059

Invergo BM, Montanucci L, Koch KW, Bertranpetit J, Dell Orco D. (2013) Exploring the rate-limiting steps in visual phototransduction recovery by bottom-up kinetic modeling. Cell Commun Signal May 21; 11(1):36

Zägel P, Dell'Orco D, Koch KW (2013) The dimerization domain in outer segment guanylate cyclase is a Ca2+-sensitive control switch module. Biochemistry 2013, 52, 5065-5074

Fries R, Scholten A, Säftel W, Koch KW (2013) Zebrafish Guanylate Cyclase Typ 3 Signaling in Cone Photoreceptors. PLOS ONE 10.1371

Beste KY, Spangler CM, Burhenne H, Koch K-W, Shen Y, et al. (2013) Nucleotidyl Cyclase Activity of Particulate Guanylyl Cyclase A: Comparison with Particulate Guanylyl Cyclases E and F, Soluble Guanylyl Cyclase and Bacterial Adenylyl Cyclases Cyaa and Edema Factor. PLoS ONE 8(7): e70223. doi:10.1371/journal.pone.0070223

Publikationen 2014

Dell'Orco D, Sulman S, Zägel P, Marino V, Koch KW (2014) Impact of cone dystrophy-related mutations in GCAP1 on a kinetic model of phototransduction. Cell Mol Life Sci, Feb 25 [Epub ahead of print]

Zägel P and Koch K-W (2014) Dysfunction of outer segment guanylate cyclase caused by retinal disease related mutations. Front Mol Neurosci., 7:4    

Sulmann S, Dell'Orco D, Marino V, Behnen P, Koch KW (2014) Conformational Changes in Calcium-Sensor Proteins under Molecular Crowding Conditions. Chem. Eur. J. 20, 6756-6762

Invergo BM, Dell'Orco D, Montanucci L, Koch KW, Bertranpetit J (2014) A comprehensive model of the phototransduction cascade in mouse rod cells. Mol. BioSyst., 10, 1481-1489

Köster M, Dell'Orco D, Koch KW (2014) The interaction network of rhodopsin involving the heterotrimeric G protein transducin and the monomeric GTPase Rac1 is determined by distinct binding processes. FEBS J Sep 22 doi 10.111/febs.13064 [Epub ahead of print ]

Marino V, Sulmann S, Koch KW, Dell'Orco D. (2014) Structural effects of Mg2+ on the regulatory states of three neuronal calcium sensor operating in vertebrate phototransduction. Biochim Biophys Acta. 2014 Nov 4. pii: S0167-4889(14)00385-1. doi: 10.1016/j.bbamcr.2014.10.026. [Epub ahead of print]