Biochemistry of neurosensory processes/ signal transduction

Publications 2015

Marino, V., Sulmann, S., Koch, K.-W., and Dell’Orco, D. (2015) Structural effects of Mg2+ on the regulatory states of three neuronal calcium sensors operating in vertebrate phototransduction. Biochim. Biophys. Acta 1853, 2055-2065.

Zernii, E.Y., Grigoriev, I.I., Nazipova, A.A., Scholten, A., Kolpakova, T.V., Zinchenko, D.V., Kazakov, A.S., Senin, I.I., Permyakov, S.E., Dell'Orco, D., Philippov, P.P. and Koch, K.-W. (2015) Regulatory function of the C-terminal segment of guanylate cyclase-activating protein 2. Biochim. Biophys. Acta. 1854, 1325-1337.

Marino, V., Scholten, A., Koch, K.-W. and Dell'Orco, D. (2015) Two retinal dystrophy-associated missense mutations in GUCA1A with distinct molecular properties result in a similar aberrant regulation of the retinal guanylate cyclase. Hum. Mol. Genet. 24, 6653-6666. doi: 10.1093/hmg/ddv370

Koch, K.-W. and Dell'Orco, D. (2015) Protein and signaling networks in vertebrate photoreceptor cells. Front. Mol. Neurosci. Vol.8, Article 67

Dell'Orco D. and KW. Koch (2015) Transient Complexes between Dark Rhodopsin and Transducin: Circumstantial Evidence or Physiological Necessity? Biophys J. Feb 3; 108(3) 775-7.

Sulmann S., Vocke F., Scholten A. and Karl-Wilhelm Koch (2015) Retina specific GCAPs in zebrafish acquire functional selectivity in Ca2+-sensing by myristoylation and Mg2+-binding. Scientific Reports, 5: 11228

Robin J, Brauer J, Sulmann S, Marino V, Dell'Orco D, Lienau C and Koch KW (2015) Differential nanosecond protein dynamics in homologous calcium sensors. ACS Chem Biol10, 2344–2352.

Publications 2016

Tena-Campos, M., Ramon, E., Lupala, C.S., Pérez, J.J., Koch, K.-W. and Garriga, P. (2016) Zinc Is Involved in Depression by Modulating G Protein-Coupled Receptor Heterodimerization. Mol. Neurobiol. Mol. Neurobiol. 53(3), 2003-2015.doi:10.​1007/​s12035-015-9153-y

Sulmann, S., Wallisch, M., Scholten, A., Christoffers, J. and Koch, K.-W. (2016) Mapping Calcium-sensitive Regions in the Neuronal Calcium Sensor GCAP2 by Site Specific Fluorescence Labeling. Biochemistry 55, 2567-2577.

Dell'Orco, D. and Koch, K.-W. (2016) Fingerprints of Calcium-Binding Protein Conformational Dynamics Monitored by Surface Plasmon Resonance. ACS Chem Biol. 11, 2390-2397.